Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice

[ofonorow]

Hypoascorbemia induces atherosclerosis and vascular deposition of lipoprotein(a) in transgenic mice
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447075/


It was noticed early on (at least a decade ago) after they first created mice with the GULO defect preventing them from making vitamin C - that these mice would suffer atherosclerosis.

This connection with Lp(a) is interesting as the mice (which normally make their own vitamin C) shouldn't have had an evolutionary reason to make Lp(a) - one would think.

[Johnwen]

[OxC]

[Johnwen]

[OxC]

Which is why orange juice is not a good source of V-C...Taking V-C with any form of sugar is never a good idea!
Drinking Orange juice a good source of Citric acid and is also not a very good source of V-C

That is basically what I asked. Thanks.

[JohnCCha]

[OxC]

With this, I would like to address some key points that were not understood/misunderstood.

Thank you Mr. Cha for coming here to address these points. I'm pleased that the first author on the study under discussion would take the time to do so. I personally found your research very interesting and important, and your comment that "Maeda DID NOT find atherosclerosis in the Gulo-/- mouse with total vitamin C deprivation..." points to the important difference that in your study, you demonstrated the actual vascular deposition of lipoprotein(a) under hypoascorbemic conditions.

The transgenic knockout mouse is a system to study human atherogenesis in a mouse. Some things are the same, other things are different such as size and dimension.

It occurs to me that your particular mouse model might be appropriate to assess the question of whether the inclusion in the diet of large amounts of proline/lysine actually can help prevent the deposition of lipoprotein(a).

All the best to you also, and Happy New Year!

[JohnCCha]

"It occurs to me that your particular mouse model might be appropriate to assess the question of whether the inclusion in the diet of large amounts of proline/lysine actually can help prevent the deposition of lipoprotein(a)."

Yes, that is what question naturally follows, Mr. OxC. I am putting together the results right now of ascorbate + l-lysine + niacin in respect to shrinking down pre-formed atherosclerotic plaque.